Advancing Women’s Cardiovascular Health

Non-invasive cardiovascular assessment across the female life span

Cardiovascular assessment from pregnancy to menopause

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Seeing beyond conventional blood pressure

1 in 5 pregnancies is affected by hypertensive disorders globally. ~8% develop preeclampsia, a leading cause of maternal mortality and morbidity. Women who experience it carry a 72% higher lifetime cardiovascular risk.

Yet today, 50% of preeclampsia cases are missed before term. Pregnancy acts as a cardiovascular stress test. Hypertensive disorders are early markers of systemic CVD risk, not just pregnancy complications.


"An altered prepregnancy hemodynamic phenotype is associated with the subsequent development of preeclampsia/fetal growth restriction.
Foo et al., Hypertension, 2018
"First-trimester cardiac output is an independent predictor of preeclampsia and small for gestational age.”"
De Paco et al., Obstetrics & Gynecology, 2008
"The use of a computerized brachial blood pressure cuff allows for noninvasive measurement of cardiac output, stroke volume and total peripheral resistance.”
DeVore et al.
"Maternal hemodynamic interrogation … considers not only the peripheral blood pressure but also the entire cardiovascular system."

Ferrazzi et al., AJOG, 2018
"Increased maternal arterial stiffness preceded the clinical onset of PE."
Mansukhani et al., King's College London, AJOG, 2024
"Hemodynamically triggered antihypertensive therapy can improve outcomes for both mother and child."
Loheit et al., 2026

Understand Maternal Hemodynamics in Pregnancy

Pregnancy requires major cardiovascular adaptation. Non-invasive pulse wave analysis provides insight into cardiac output, vascular resistance, central blood pressure and other cardiovascular parameters, helping clinicians characterize maternal hemodynamic profiles beyond conventional blood pressure measurement.

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Investigating Hemodynamic Markers of Preeclampsia Risk

Preeclampsia is closely linked to abnormal maternal vascular adaptation. Evaluating hemodynamic and vascular biomarkers for earlier risk assessment. The PERI Score is under development to investigate associations between these signals and maternal cardiovascular risk.

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Supporting Research toward Personalized Cardiovascular Care

Women's cardiovascular risk evolves across the life course. Our research platform combines validated cardiovascular measurements with investigational digital biomarkers to explore individualized cardiovascular profiling.

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